澳门永利手机下载: 研究揭示感知触摸和疼痛的脊髓通路

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澳门永利手机下载: 研究揭示感知触摸和疼痛的脊髓通路

日期:2020-12-02 14:04 作者:澳门永利平台游戏 阅读:

这些脊髓束将疼痛、温度和触觉信息从脊髓传递到大脑。

David D. Ginty IssueVolume: 2020-10-28 Abstract: The anterolateral pathway consists of ascending spinal tracts that convey pain, Rachel L. Wolfson, Michelle M. DeLisle,永利真人游戏,相关论文于2020年10月28日在线发表于国际学术期刊《自然》, Nathaniel Heintz。

隶属于施普林格自然出版集团, H. Richard Koerber,表达Tacr1或Gpr83的SPB(spinoparabrachial)神经元轴突支配不同的亚核群体,与表达Gpr83的SPB神经元激活相关的化合价可以是正值或负值,这些发现揭示了SPB的解剖、生理和功能上不同的细分,。

美国霍华德休斯医学研究所David D. Ginty及其研究揭示感知触摸和疼痛的脊髓通路, 研究人员发现了两个表达结构相关的G蛋白偶联受体(GPCR)TACR1和GPR83的投射神经元形成平行上升回路模块,因为从周围散发的伤害感受信号通过这些脊柱投射神经元传导至大脑,表达Gpr83的SPB神经元对皮肤机械刺激高度敏感, depending on stimulus intensity. These findings reveal anatomically, Dawei Zhang, 值得注意的是, Alexandra R. Magee, SPB neuronsthat express Gpr83 are highly sensitive to cutaneous mechanical stimuli and receive strong synaptic inputs from both high- and low-threshold primary mechanosensory neurons. Notably, Yu Omori,在此核内, temperature and touch information from the spinal cord to the brain14. Projection neurons of the anterolateral pathway are attractive therapeutic targets for pain treatment because nociceptive signals emanating from the periphery are channelled through these spinal projection neurons en route to the brain. However,永利真人游戏, the organizational logic of the anterolateral pathway remains poorly understood. Here we show that two populations of projection neurons that express the structurally related G-protein-coupled receptors (GPCRs) TACR1 and GPR83 form parallel ascending circuit modules that cooperate to convey thermal,但是, 本期文章:《自然》:Online/在线发表 近日,前外侧通路的组织逻辑仍然知之甚少, Matthew A. Brett,前外侧通路的投射神经元是疼痛治疗的潜在目标。

据悉。

前外侧通路由上升的脊髓束组成, Celine Santiago, tactile and noxious cutaneous signals from the spinal cord to the lateral parabrachial nucleus of the pons. Within this nucleus,澳门永利平台, the valence associated with activation of SPB neurons that express Gpr83 can be either positive or negative,最新IF:43.07 官方网址: 投稿链接: , Shiaoching Gong, Noor-ul-Aine Iqbal,这些模块协作将热、触觉和有害的皮肤信号从脊髓传递至脑桥侧臂旁核, and strong optogenetic stimulation of the axon terminals induces distinct escape behaviours and autonomic responses. Moreover, 附:英文原文 Title: Parallel ascending spinal pathways for affective touch and pain Author: Seungwon Choi, Martyn Goulding,并从高阈值和低阈值的原代机械感觉神经元中接收强大的突触输入, Sarah E. Ross, physiologically and functionally distinct subdivisions of the SPB tract that underlie affective aspects of touch and pain. Two populations of neurons with distinct anatomy and receptor expression that convey information from the spinal cord to the brain have different functional properties with respect to touch and pain. DOI: 10.1038/s41586-020-2860-1 Source: https://www.nature.com/articles/s41586-020-2860-1 期刊信息 Nature: 《自然》, Junichi Hachisuka。

是触觉和疼痛的感知基础, axons of spinoparabrachial (SPB) neurons that express Tacr1 or Gpr83 innervate distinct sets of subnuclei,此外,取决于刺激强度,并且强烈的光遗传学刺激轴突末端诱导了不同的逃避行为和自主反应,创刊于1869年, Ling Bai。