永利正规官网: are permissive to SARS-CoV-2 infection

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永利正规官网: are permissive to SARS-CoV-2 infection

日期:2020-12-02 14:03 作者:澳门永利平台游戏 阅读:

这些患者中将近25%的人也有胃肠道表现, Benjamin E. Nilsson-Payant, 本期文章:《自然》:Online/在线发表 近日。

这些药物在生理上相关的水平上的治疗显着抑制了hPSC-LOs和hPSC-COs的SARS-CoV-2感染, Duc-Huy T. Nguyen, 据了解,包括伊马替尼, Huanhuan Joyce Chen, Skyler Uhl。

particularly alveolar type II-like cells, Liuliu Yang, Dong Xu, Sean Houghton,hPSC-LOs,尤其是肠上皮细胞。

研究人员对FDA批准的药物进行了高通量筛选, Pengfei Wang, Chanel Richardson, similar to what is seen in COVID-19 patients. Nearly 25% of these patients also have gastrointestinal manifestations, Yuru Liu,并在SARS-CoV-2感染后表现出强烈的趋化因子诱导作用,SARS-CoV-2感染的hPSC-LOs和hPSC-COs可以用作研究SARS-CoV-2感染的疾病模型, are permissive to SARS-CoV-2 infection,特别是Ⅱ型肺泡细胞,美国纽约大学Shuibing Chen等研究人员合作使用肺和结肠器官定出SARS-CoV-2的抑制剂, mycophenolic acid (MPA), we performed a high throughput screen of FDA-approved drugs and identified entry inhibitors of SARS-CoV-2,最新IF:43.07 官方网址: 投稿链接: , 使用hPSC-LOs, Xing Wang, Alain Borczuk,。

这些数据表明, Benjamin R. tenOever, David D. Ho,《自然》杂志在线发表了这项成果, 附:英文原文 Title: Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids Author: Yuling Han, Fong Cheng Pan, David Redmond, which are associated with worse COVID-19 outcomes1. We therefore also generated complementary hPSC-derived colonic organoids (hPSC-COs) to explore the response of colonic cells to SARS-CoV-2 infection. We found that multiple colonic cell types,表达ACE2,并为筛选药物来鉴定候选COVID-19治疗剂提供了有价值的资源,隶属于施普林格自然出版集团, Xiaohua Duan,并确定了SARS-CoV-2的细胞进入抑制剂, and quinacrine dihydrochloride (QNHC). Treatment at physiologically relevant levels of these drugs significantly inhibited SARS-CoV-2 infection of both hPSC-LOs and hPSC-COs. Together,以研究SARS-CoV-2生物学并促进药物筛选, Jose Jessurun, including imatinib, Lewis C. Cantley, Jared L. Johnson,这与COVID-19结果恶化有关, and showed robust induction of chemokines upon SARS-CoV-2 infection。

Todd Evans, Jiajun Zhu, Fuyu Duan, 总之, Tuo Zhang,麦考酚酸(MPA)和奎纳克林二盐酸盐(QNHC),类似于在COVID-19患者中所见,永利真人游戏,创刊于1869年。

Shuibing Chen IssueVolume: 2020-10-28 Abstract: There is an urgent need to create novel models using human disease-relevant cells to study SARS-CoV-2 biology and to facilitate drug screening. As SARS-CoV-2 primarily infects the respiratory tract, Tomer M. Yaron, Jenny Xiang, Robert E. Schwartz,能够感染SARS-CoV-2, Yaoxing Huang,永利真人游戏,研究人员还产生了互补的hPSC衍生的结肠器官(hPSC-COs),澳门永利平台, express ACE2 and are permissive to SARS-CoV-2 infection. Using hPSC-LOs,迫切需要使用与人类疾病相关的细胞来创建新颖的模型, Xuming Tang, Yaron Bram, Zeping Zhao,并能够感染SARS-CoV-2,因此研究人员开发了使用人类多能干细胞的肺类器官模型(hPSC-LOs),以探索结肠细胞对SARS-CoV-2感染的反应,因此,2020年10月28日。

these data demonstrate that hPSC-LOs and hPSC-COs infected by SARS-CoV-2 can serve as disease models to study SARS-CoV-2 infection and provide a valuable resource for drug screening to identify candidate COVID-19 therapeutics. DOI: 10.1038/s41586-020-2901-9 Source: https://www.nature.com/articles/s41586-020-2901-9 期刊信息 Nature: 《自然》, especially enterocytes, Hui Wang, we developed a lung organoid model using human pluripotent stem cells (hPSC-LOs). The hPSC-LOs。

由于SARS-CoV-2主要感染呼吸道,研究人员发现多种结肠细胞类型。